DL has qualified staff...

Genetic Toxicology

Genetic toxicology...


Biocompatibility is, by...


In Vivo pharmacology...


In vitro ADME screens...
Home »  Adme/Dmpk


In vitro ADME screens provide critical information for lead optimization and selection of the appropriate species for conduct of toxicological studies. Elucidation of the interaction of a test substance under investigation using human cytochrome(s) P450 (CYP) and other drug-metabolizing enzymes is important for predicting its potential for interaction with other drugs which is of great relevance in the planning of clinical studies.

At present DL has capability to conduct the following studies

Absorption Studies
  • Cell permeability assays (Caco-2 and MDCK cells)
  • Parallel Artificial Membrane Permeability Assay (PAMPA)
  • Clearance and half life determination
Physico-Chemical Studies
  • Solubility studies for NCE – Kinetic and Equilibrium solubility
  • Determination of Log P and Log D
DMPK: These are the type of studies that are conducted to determine the disposition of the drug and its metabolites using suitable animal models. At DL we offer the following DMPK services

  • Single or multiple dose (s) – in mice & rats
  • Oral &/or IV or IP (or intended) route
  • 2-6 animals/dose; 5-12 time points / client specific designs
  • PK study in cannulated animals as per client's requirement
  • Tissue distribution studies
  • Oral Bioavailability
  • Elimination half life (t1/2) Clearance (Cl) Volume Distribution (Vd)
  • Metabolite identification